Drug combination prevents HIV infection in animal study

While Native American cultures have long honored people of integrated genders, a new documentary looks at a shocking hate crime against a two-gendered Colorado teenager.

What's it like to be 33, gay, and one of the most powerful people in America's second-largest city? Stressful, says Matt Szabo, the new deputy chief of staff to Los Angeles mayor Antonio Villaraigosa.

Gay fanpires are sure to flock to New Moon, but with questions lingering about author Stephanie Meyer and the cash she gives to the Mormon Church, Mike Albo wonders if we'd be better off tying a clove of garlic around our necks.

A church-turned-shelter for homeless youth in Queens, New York is a far cry from sleeping on the streets after a $200,000 renovation and a partnership with the Ali Forney Center for LGBT youth.

He's opened for Britney and Katy Perry, kept Dita Von Teese company in the front row at Paris Fashion Week, and gets name-checked on Twitter by Lady Gaga, Miley Cyrus, and Sarah Silverman. So who the hell is Sliimy, anyway?

Now that new government guidelines are out on how to best care for your breasts, lesbians, bisexuals, and transgender women are left with a lot of questions.

The loss of marriage equality in Maine was a major blow on Election Night, but down the coast in North Carolina there was an LGBT victory. Pam Spaulding talks to Chapel Hill's mayor-elect, Mark Kleinschmidt.

When performance-art drag diva Joey Arias combines forces with master puppeteer Basil Twist, anything — no, seriously, anything — can happen.

Dave White recaps as Oprah plays nice with Palin in her exclusive, personality-rehabbing interview. Topics include Katie Couric ("badgering"), Levi Johnston ("Ricky Hollywood"), and step class ("gee, it's fun").

This week Congressman Barney Frank laid out a plan and a timetable for repealing "don't ask, don't tell..." and a reminder that he's been saying it would happen in 2010 from the beginning.

Mitrice Richardson is a 4.0 student, a former beauty pageant contestant, and a lesbian. She’s also been missing since September, and her family and girlfriend want answers. 

The Advocate’s queen on the New York theater scene meets bisexual conjoined twins, pits Sienna Miller against Jude Law, tastes Cheyenne Jackson’s Rainbow, and saves up for a rainy day with Hugh Jackman.

Controversial artist Shepard Fairey spends his creative capital to bring marriage equality back to California.

We'll let you decide whether 2012 is spectacular, Armageddon-tinged eye candy or a hot mess. Plus: A new take on gay romance with Dare.

Love her or loathe her, drag queen Porsche sidekicks The Wanda Sykes Show into shape.

Hipster actor Jason Schwartzman gets schooled on his gay fans and the Hollywood closet and reveals why he’s never played a gay role.

Soap icon and six-time Emmy Award winner Erika Slezak talks about the trials and tribulation of playing Victoria Lord and her run for mayor, gay rights, and the sudden death that rocks Llanview.

The military continues to operate under the “don’t ask, don’t tell” policy, which even the Pentagon says is unsubstantiated. As General McChrystal asks for more troops in Afghanistan, one gay Navy vet offers his service to his country in spite of the policy that would deny him.

Ford Motor Co. and Reynolds American, two companies that receive consistently high marks from the HRC, have ties with Schubert Flint Public Affairs, the firm that was instrumental in defeating marriage equality in California and Maine.

In honor of Veteran's Day, two of the most famous gay vets -- Frank Kameny and Dan Choi -- share their letters from Uncle Sam.