Merck begins human tests of HIV vaccines
BY Advocate.com Editors
September 09 2003 12:00 AM ET
Scientists at Merck and Co.'s vaccine research headquarters in suburban Philadelphia are testing two experimental HIV vaccines in early human trials. In earlier laboratory tests, the vaccines did not prevent monkeys from contracting a simian version of HIV but did control the virus in the animals so that the monkeys never developed AIDS. The company is now conducting 10 Phase I human studies involving 1,300 volunteers around the country. The studies will explore the vaccine's safety and record any immune response. Later tests will determine whether the vaccine prevents people from developing AIDS. Results from the Phase I trials are expected next year. If test results are promising, studies on the vaccine's effectiveness in humans could take another few years, until 2008 or 2009.
Merck's lead vaccine uses a common-cold adenovirus to carry genetic material from HIV into the body in order to produce an immune response. In Merck's monkey studies, a "naked DNA" inoculation with an adenovirus booster produced the best immune response.
- 'Old Redneck Hillbilly' Husband of Kim Davis Has a Warning for Nosey People
- Why Are We Gay?
- Meet the Trans Man and Pansexual Woman Married by Kentucky Clerk Kim Davis
- The Top 175 Essential Films of All Time for LGBT Viewers
- 14 Ex-Ex Gays Paving the Way Forward
- Op-ed: How The Danish Girl Helped Me Discover Myself