New studies show how quickly HIV destroys immune system cells
March 29 2005 12:00 AM ET
Within days of infection, HIV destroys more than half of the immune cells that might recognize and help fight it--a finding that may force a reevaluation of how to tackle the deadly infection, two teams of U.S. researchers reported. Two separate studies in monkeys showed that SIV, the monkey version of HIV, attacks CD4 memory T cells right away and wipes out more than half of them. "The findings may require a rethink of strategies to design anti-HIV drugs and vaccines," Mario Roederer of the National Institute of Allergy and Infectious Diseases and colleagues said in one of two reports published in the journal Nature.
Both teams worked with monkeys that they infected with SIV. They watched what happened to their immune cells. Right away the virus attacked the CD4 T cells that had the correct configuration for the virus. Normally during an infection such cells would recognize and latch onto an invader, helping other components of the immune system destroy it. But HIV is different because it targets the immune system, and the two studies show how quickly it makes it impossible for its victims to launch a defense.
Roederer's team used new, sensitive tests to show just how the virus moves so quickly. "Specifically, 30% to 60% of CD4 memory T cells throughout the body are infected by SIV at the peak of infection, and most of these infected cells disappear within four days," they wrote. "Furthermore, our data demonstrate that the depletion of memory CD4 T cells occurs to a similar extent in all tissues. As a consequence, over one-half of all memory CD4 T cells in SIV-infected macaques are destroyed directly by viral infection during the acute phase--an insult that certainly heralds subsequent immunodeficiency."
This means any attempt to vaccinate against HIV or to provide efficient treatment must stop this process right away.
Ashley Haase of the University of Minnesota Medical School and colleagues made similar findings. Not only does the virus directly kill the CD4 cells, they found, but it also causes them to commit cell suicide. (Reuters)