Researchers at
Brigham and Women's Hospital in Boston are urging
that U.S. HIV-treatment guidelines be changed to
include drug-resistance testing for all HIV patients
before antiretroviral therapy is initiated because
of the likelihood that they may have been infected with
virus already resistant to one or more anti-HIV drugs.
Currently, drug-resistance tests are usually offered
only to HIV patients who are experiencing treatment
failure to help pinpoint which of their medications is
no longer effective in stopping HIV replication.
Pretreatment testing both improves the survival of patients
and is cost-effective, the researchers write in the
November 1 issue of the journal Clinical Infectious
Diseases, which is now available online.
Using a computer
model comparing patient survival times and cost of
drug-resistance testing, the researchers discovered that
frontline testing increased patient survival by up to
15 months and was highly cost-effective compared with
other tests and intervention routines done for both
HIV-positive and HIV-negative patients.
"Unfortunately,
HIV drug resistance, which now is found in 8% to 10%
of all newly diagnosed HIV patients, is on the rise," says
researcher Paul Sax in a press release. "The good news
today is that we have demonstrated resistance testing
at the time of diagnosis--before treatment
begins--is a strategy that can increase survival at a
very reasonable cost to patients, hospitals, and
insurers."
The resistance
test BWH currently uses costs approximately $400, and it
is likely to continue dropping in price, according to Sax.
This up-front cost is less than 0.2% of the total
lifetime cost of caring for an HIV-positive person,
making the test extremely cost-effective.
"With more than
20 anti-HIV medications currently available, genotype
resistance testing prior to the start of therapy can help
offer patients an individualized treatment plan," says
Sax in a press release. "Based on our
cost-effectiveness model, we are urging HIV clinicians
to consider testing for resistance in untreated patients
right away at the time of diagnosis. Patients should
also talk to their doctors about this new approach.
There is no longer a good reason to wait."
The study was
funded by the National Institutes of Health and the Centers
for Disease Control and Prevention. (Advocate.com)