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Switching from
AZT results in only slight reversal of lipoatrophy
Fat loss from patients' limbs can be reversed slightly when Viread or Ziagen is substituted for AZT.
HIV-positive adults experiencing fat loss from their limbs experience a slight reversal of lipoatrophy when switching from AZT to either Viread or Ziagen, according to a study presented at 10th European AIDS Conference, AIDSmap.com reports. Switching from Zerit (d4T) to Viread or Ziagen posted much better gains in limb fat, according to the study. The researchers followed 105 HIV-positive patients experiencing fat loss and determined that after 48 weeks those who replaced AZT gained a median 66 grams of limb fat when switching to Viread and 210 grams when switching to Ziagen. By comparison, those switching from Zerit to Viread posted a median 529-gram limb fat gain, and those replacing Zerit with Ziagen achieved a 357-gram gain. Other factors associated with a lower fat-loss recovery included older age, Caucasian ethnicity, and longer duration of antiretroviral therapy, according to the study. (Advocate.com)
