The suspects are charged with murdering Serena Angelique Velázquez and Layla Pelaez after discovering the women were trans.
The men have been detained in connection with the deaths of Serena Angelique Velázquez and Layla Pelaez but have not been charged.
Penélope Díaz Ramírez, killed at the Bayamon correctional complex, was also the fifth trans person murdered in the U.S. territory this year.
Serena Angelique Velázquez and Layla Pelaez are the third and fourth trans people killed in the territory this year, and the eighth and ninth in the U.S. as a whole.
Yampi Méndez Arocho, shot to death last week, is the second trans person murdered in the territory this year.
Alexa Negrón Luciano was killed not long after being reported for using a women's restroom at a McDonald's.
He called lawmakers and journalists "cocksuckers" and "whores." Now he's resigned as governor of Puerto Rico.