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BMS files for FDA approval of protease inhibitor Zrivada

Pharmaceutical company Bristol-Myers Squibb this week applied for Food and Drug Administration approval of its experimental second-generation protease inhibitor Zrivada (atazanavir). The FDA application included data from Phase III clinical trials showing that the once-a-day drug is as effective as other protease inhibitors and does not cause blood lipid levels to rise, a problem common with existing protease drugs. More than 2,400 people have participated in studies of Zrivada, which is currently available through an early-access program for patients who have failed other anti-HIV medications. A decision by the FDA is expected by early summer.

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Lev Radin/Pacific Press/LightRocket via Getty Images
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Leather underpants hang on the shelf in a store for fetish fashion and sex toys.

Michael Brandt/picture alliance via Getty Images
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U.S. Health and Human Services Secretary Robert F. Kennedy Jr. (L) and Food and Drug Administration Commissioner Marty Makary (2nd L) attend an announcement at the Department of Health and Human Services on December 18, 2025 in Washington, DC.

Alex Wong/Getty Images
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