Here’s more proof of why it’s so important for you and your primary caregiver to select the most effective and best-tolerated initial antiretroviral regimen. A study presented at the Ninth International Congress on Drug Therapy in HIV Infection has shown that treatment failure is twice as likely to occur with a second-line regimen as with first-line treatment. So be sure to be candid with your physician about your specific needs, lifestyle issues, side-effect fears, and treatment expectations when you both decide the time is right for you to start anti-HIV meds.