CONTACTAbout UsCAREER OPPORTUNITIESADVERTISE WITH USPRIVACY POLICYPRIVACY PREFERENCESTERMS OF USELEGAL NOTICE
© 2025 Pride Publishing Inc.
All Rights reserved
All Rights reserved
By continuing to use our site, you agree to our Private Policy and Terms of Use.
The Food and Drug Administration on Tuesday approved a new protease inhibitor developed by GlaxoSmithKline and Vertex Pharmaceuticals. The drug, originally known as 908 but now dubbed Lexiva, is a pro-drug version of the protease inhibitor Agenerase. Pro-drugs are inactive substances that are converted into an effective medication by the body's enzymes or other metabolic processes, which can avoid some of the toxic side effects of medications that do not require enzyme activation. Lexiva is taken as two tablets either once or twice per day, depending on dosage strength. Patients who have taken other antiretrovirals should take Lexiva twice per day, company officials say. Vertex announced in July that Phase III clinical trial data showed Lexiva was slightly less effective in suppressing HIV viral loads than Abbott Laboratories' protease inhibitor Kaletra in a first-line drug regimen but that Lexiva was as potent as Kaletra for HIV patients already treated with antiretroviral drugs. Lexiva is approved for use as part of a multidrug cocktail for HIV-positive adults. The drug will be available in 700-milligram tablets.
From our Sponsors
Most Popular
31 Period Films of Lesbians and Bi Women in Love That Will Take You Back
December 09 2024 1:00 PM
18 of the most batsh*t things N.C. Republican governor candidate Mark Robinson has said
October 30 2024 11:06 AM
True
After 20 years, and after tonight, Obama will no longer be the Democrats' top star
August 20 2024 12:28 PM
Trump ally Laura Loomer goes after Lindsey Graham: ‘We all know you’re gay’
September 13 2024 2:28 PM
Melania Trump cashed six-figure check to speak to gay Republicans at Mar-a-Lago
August 16 2024 5:57 PM
Latest Stories
Trump’s new White House Press Secretary targets transgender people in first briefing
January 28 2025 6:24 PM
Jeremy Allen White to star as a bisexual man in upcoming Netflix romance
January 28 2025 5:44 PM
Trump signs executive order banning federal support of gender-affirming care for anyone under 19
January 28 2025 5:25 PM
True
Elon Musk denied his dream West Wing office, and the Internet rejoices
January 28 2025 4:50 PM
Pete Buttigieg eyeing potential Michigan U.S. Senate race
January 28 2025 4:48 PM