A study in
Proceedings of the National Academy of
Sciences suggests that two key human genes may have the
ability to destroy HIV genetic material inside immune
system cells. The study, conducted by researchers at
Ohio State University, shows that genes XPB and XPD,
which work in the body to repair damaged or faulty human
DNA, also work to destroy HIV genetic material by
degrading viral DNA. The researchers say that their
discovery suggests the proteins could provide a
natural defense against HIV infection and could lead to new
treatments for HIV disease.
findings identify a new drug target, one that involves a
natural host defense," researcher Richard
Fishel told BBC News. "HIV treatments that
target cellular components should be far less likely to
develop resistance." (The Advocate)
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