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Vertex, Glaxo file for FDA approval of investigational protease inhibitor

Officials from pharmaceutical companies GlaxoSmithKline and Vertex Pharmaceuticals Inc. announced Friday that they have filed a new drug application with the Food and Drug Administration for their investigational, second-generation protease inhibitor known as GW433908 or simply 908. The companies also filed on the same day for European Union approval of the drug. The submissions include data from more than 1,100 patients who have participated in Phase III trials to evaluate the safety and efficacy of 908 in comparison with two widely used HIV protease inhibitors. In clinical trials, 908 was shown to reduce HIV viral loads to undetectable levels in about 70% of previously untreated HIV-positive adults with advanced HIV disease. The companies, which jointly developed the drug, hope to have it approved for marketing in the United States by the second half of 2003.

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donald trump gestures to his head
National

Urgent 25th Amendment calls grow after Trump threatens mass destruction of Iran's civilization

Calls for removal are escalating as the president’s violent language blurs the line between attacking Iran’s government and committing genocide against its people.

kim reynolds smiling and holding up a finger
States

Iowa can enforce previously blocked ‘don’t say gay’ law, appeals court rules

The decision means schools can restrict certain books and LGBTQ+ topics in class while courts continue to weigh the law’s constitutionality.

Split image of protest signs reading “My Body My Choice” and “Trans Rights Are Human Rights” at demonstrations
Opinion

Attacks on abortion and gender-affirming care are inextricably linked

Opinion: Lawmakers are using the same tactics, including criminalization, surveillance, and restrictions on young people to limit access to both abortion and gender-affirming care, write state policy experts with the National LGBTQ Task Force and the Guttmacher Institute.

demonstrators holding protect lgbtq families and conversion therapy hurts kids hurts families hurts faith signs
National

The Supreme Court’s conversion therapy ruling is being misunderstood

The justices focused on how the law was written, not the science behind conversion therapy. But the impact could still be significant.

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Doctors’ group says American Medical Association didn’t retreat on gender-affirming care for minors

doctor examining a toddler with a parent holding the child

A pediatrician examines a child in the Alcorn State University clinic in Lorman, Mississippi.

Alcorn State University via Getty Images
The American Medical Association is rejecting claims it has stepped back from support for gender-affirming care, saying its guidance remains unchanged even as political pressure and public confusion intensify. Keep Reading →

Kids can be subjected to harmful 'conversion therapy,’ U.S. Supreme Court rules

person wears conversion therapy sucks t-shirt

A man wears a shirt reading "conversion therapy sucks" outside the US Supreme Court as the Court hears oral arguments in Chiles v. Salazar, a landmark case on "conversion therapy," on October 7, 2025, in Washington, DC.

ANDREW CABALLERO-REYNOLDS/AFP via Getty Images
The U.S. Supreme Court on Tuesday, on Transgender Day of Visibility, struck down Colorado’s ban on so-called “conversion therapy” for minors. The decision elevates abstract free-speech doctrine over a growing body of medical evidence and leaves LGBTQ+ youth more exposed to a practice doctors have long described as harmful. The Court ruled 8–1, with a broad majority, including two liberal justices, joining the opinion striking down the law, and Justice Ketanji Brown Jackson dissenting. Keep Reading →

This Trans Day of Visibility, help these 5 trans people afford gender-affirming surgery costs

A person smiles for a selfie.

Jack Lea of California has launched a GoFundMe campaign to help cover costs from his top surgery.

Photo Courtesy of GoFundMe
Tuesday is Trans Day of Visibility, an annual day of observance on March 31 focused on highlighting trans history and issues affecting the trans community. Keep Reading →

Ron DeSantis signs law restoring short-term HIV medication access for needy Floridians

ron desantis golfing

Florida Gov. Ron DeSantis looks on during the pro-am prior to the Valspar Championship on the Copperhead Course at Innisbrook Resort and Golf Club on March 18, 2026, in Palm Harbor, Florida.

Cliff Hawkins/Getty Images
This story was originally reported by Orion Rummler of The 19th. Meet Orion and read more of their reporting on gender, politics and policy. Keep Reading →

ACT UP marks 39th anniversary with NYC die-in at Palantir over Trump administration contracts

Protesters holding signs lie in a city street with their eyes closed.
Protesters lie outside Palantir's office in Manhattan as part of the die-in staged by ACT UP New York.
Jack Walker for The Advocate
In the middle of a busy New York City street, dozens of people lay still atop the pavement on Saturday afternoon. ACT UP, one of the world’s most prominent HIV advocacy groups, organized the demonstration outside Palantir, a software company that develops surveillance technology and contracts with Immigration and Customs Enforcement. Keep Reading →
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