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Rare and aggressive drug-resistant HIV reported in New York

Rare and aggressive drug-resistant HIV reported in New York

New York City health officials are working to track down sex partners of a man diagnosed with a rare strain of highly drug-resistant HIV that progressed rapidly to AIDS. The virus was found in a man in his mid 40s who had unprotected sex with other men, often while using crystal methamphetamine, an addictive stimulant, health officials said Friday. "We are not aware of another case like this in the United States or elsewhere," said Ron Valdiserri, deputy director of the Centers for Disease Control and Prevention's National Center for HIV, STD, and TB Prevention. New York health commissioner Thomas Frieden said the rare HIV strain is "difficult or impossible to treat." The New York Times, citing a person familiar with the case whom it did not identify, reports that the man was believed to have had unprotected sex with hundreds of people. The man--who had not previously undergone antiretroviral drug treatment--was diagnosed with the rare strain in December. He apparently had been infected recently after years of having unprotected anal intercourse. The city has not released his name, but health officials are trying to locate his sex partners to offer them testing. About a dozen had been identified and contacted by Sunday, the Times reports. Two of the men are currently being studied to see if they carry the more virulent drug-resistant strain of the virus. The onset of AIDS appears to have occurred within two to three months--and at most 20 months--after infection. Frieden said HIV can take 10 years to develop into AIDS. Drug resistance is increasingly common among HIV-positive people, including some who had never been treated before, but not with such a fast progression to AIDS, Valdiserri said. The man's HIV did not respond to three of four types of antiviral drugs most commonly prescribed, eliminating 19 of the 20 available anti-HIV medications; he is now receiving a fourth regimen, health officials said. Typically, drug resistance occurs after a patient is treated with the drugs, often because the patient veers from the prescribed course. In this case, resistance occurred from the start of treatment and was combined with a rapid progression to AIDS. Valdiserri said that "double whammy" of resistance and rapid progression made the case alarming: "The message to the American public is that HIV remains a very formidable adversary. We can't let down our vigilance." Some AIDS experts were skeptical about the announcement. Robert C. Gallo, codiscoverer of HIV and director of the Institute of Human Virology at the University of Maryland, said some patients progress more rapidly to AIDS because they are highly susceptible, not because their strain of the virus is more deadly. "My guess is that this is much ado about nothing," he told The New York Times. Other AIDS experts say the rapid progression of HIV in the New York City man may have been due more to unique flaws with his immune system than to the strain of the virus. Terje Anderson, executive director of the National Association of People With AIDS, is similarly cautious in his review of the case report. "It really isn't clear what one case means," he told The Washington Post. "It is premature to be talking about a 'supervirus' circulating out there in the population." But James Braun, president of the Physicians Research Network, a New York-based not-for-profit organization of clinicians serving HIV patients, said doctors have been worried for some time about a more resistant strain of the virus. "We believe that the transmission of treatment-resistant HIV was a disaster waiting to happen, particularly in communities where safer sex is not practiced regularly and in light of people using drugs like crystal meth," he said. (AP, with additional reporting by Advocate.com)

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