The network is canceling both All My Children and One Life to Live.AMC will end its run in September while OLTL will run through January.
Both shows are considered to be groundbreaking on a number of social issues, with All My Children featuring daytime television's first lesbian character and first same-sex wedding.
The show made headlines in 2000 when Bianca Montgomery (Eden Riegel), the teenage daughter of Erica Kane (Susan Lucci), came out. All My Children won numerous accolades for the story, including a GLAAD Award for the show and an Emmy for Riegel.
The show was also the first in daytime to feature a transgender character.
"It's been a fantastic journey," Lucci said in a statement to EW.com. "I've loved playing Erica Kane and working with Agnes Nixon and all the incredible people involved with All My Children. I'm looking forward to all kinds of new and exciting opportunities."
One Life to Live featured daytime's first gay teenager, played by a pre-Cruel Intentions Ryan Phillippe. The show made news in 2009 when it featured a front-burner gay romance story line.
Both shows were created by Agnes Nixon, long considered the pioneer of the daytime drama and the most socially conscious of the daytime writers.